Preheat oven to 375℉. Line a baking sheet with parchment paper.
Unroll the crescent roll dough and press into a 12x8-inch rectangle, pinching any seams together.
Spread the honey mustard sauce over the dough, leaving ½ an inch clear on the long edges and 1 inch clear on the short edges. Top with ham and cheese slices.
Starting on the short edge of the rectangle, roll the dough into a log. Pinch to seal the seam. Cut into 8 slices, about 1-inch wide. Transfer to the prepared baking sheet.
Bake for 14 to 16 minutes, or until golden.
Combine the melted butter and garlic powder in a small bowl. Brush over the tops of the pinwheels. Serve warm.