Cover a baking sheet with foil and spray with cooking spray.
Add chicken wings, flour, baking powder, cayenne pepper, garlic powder, and salt to a plastic bag. Seal the bag, then shake to coat chicken.
Place wings on the baking sheet and refrigerate for at least one hour or overnight.
Preheat oven to 425°F.
Bake wings for 20 minutes, then flip and continue to bake for 15-20 minutes more or until chicken reaches 165°F.
Meanwhile, combine melted butter and hot sauce in a small bowl. Place cooked wings in a large bowl, then pour sauce over and toss to coat. Serve immediately.
Notes
Refrigerate leftovers in a covered container for up to 3 days, or freeze in a zippered bag or container for up to a month.
Reheat wings in the microwave, air fryer, or oven. Thaw wings before reheating.